MDMA + Opioids

Medium confidence: We're pretty sure this risk rating is right, but we aren't certain.

Low risk no synergy: This combination won't do much more than the individual effects of the psychoactives involved.

Reports of people trying this psychoactive combination

“the only opioid that would have serious interactions with mdma and should be avoided regardless of the dose is tramadol. but mdma also inhibits the enzyme cyp2d6, which metabolises some opioids. so some adjustment of the dose might be advisable if you’re taking one of those.” Bluelight.

“generally a safe combo, however oxycodone will blunt the MDMA euphoria. I would save the oxy for the comedown of MDMA, that would be the best way to combine them IMO.” Bluelight.

Related research publications

We are yet to identify a research publication reporting on this combination. If you know of a publication that demonstrates the risk rating of this combination, please share the publication with us.

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