Catha edulis + Tabernathe iboga

Medium confidence: We're pretty sure this risk rating is right, but we aren't certain.

Significant risk: Danger! This is our most dangerous combination rating.

Reports of people trying this psychoactive combination

We are yet to identify an experience report on this combination. If you know of an experience report that demonstrates the risk rating of this combination, please share the experience report with us.

Related research publications

Iboga acts, among others, as an SSRI via inhibiting SERT, which is an issue because khat acts as a serotonin releaser.

Bulling, S. et al. (2012). The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters. Journal of Biological Chemistry.

Al-Motarreb, A., Baker, K. & Broadley, K. (2002). Khat: pharmacological and medical aspects and its social use in Yemen. Phytotherapy Research.

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