Cannabis and Opioids

High confidence: There is good evidence to support the risk rating of this combination.

Low risk synergy: This combination will enhance the effects of each psychoactive, or sometimes give new effects.

Reports of people trying this psychoactive combination

”…I began to smoke some high quality Cannabis out of my glass pipe… the two substances had actually complemented each other very nicely. I had completely forgotten about the hydrocodone I had taken, but now I realized that the wonderful, floaty feeling of the hydrocodone had taken the sometimes annoying body load away from the stoned feeling. I felt wonderfully high for quite a while, seeming as light as a feather… I am very experienced with cannabis, and I am no beginner with pharmeceuticals, but together, these substances are definitely very enjoyable…” Erowid.

”…I would lower the dosage of each drug, not so much because it is dangerous otherwise but just because I find that when I mix with weed with opiates I don’t need as much opiates to feel good…” Bluelight.

Related research publications

Wiese, B. & Wilson-Poe, A. (2018). Emerging Evidence for Cannabis’ Role in Opioid Use Disorder. Cannabis and Cannabinoid Research.

Cooper, Z. et al. (2018) Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability. Neuropsychopharmacology.

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